The word “isolation” gets used loosely. A Docker container is “isolated.” A microVM is “isolated.” A WebAssembly module is “isolated.” But these are fundamentally different things, with different boundaries, different attack surfaces, and different failure modes. I wanted to write down my learnings on what each layer actually provides, because I think the distinctions matter and allow you to make informed decisions for the problems you are looking to solve.
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Nature, Published online: 26 February 2026; doi:10.1038/d41586-026-00622-9